Even as there are some particular persons required to achieve your destiny, that is how some are not required to achieve it. There are destiny inhibitors as there are destiny promoters.
For you to make a tasty bitter leaf soup, you require bitter leaf, I am not saying that pumpkin leaf is bad but it is not required in the making of this soup. Its presence would rather alter the real taste of the soup. Not as if that your friend or brother is a bad person, but he may not be required in your destiny.
You have to understand that separation does not mean hatred. Are you entangled with that man or woman who hinders your dreams and aspirations, separate from him but still love him. Separate yourself from that inhibiting relationship and uphold your destiny. You do not ordinarily exist, you came for a purpose. Be responsible for your life.